Berg G, Matzkies F
Klin Wochenschr. 1975 Feb 15;53(4):187-8. doi: 10.1007/BF01466765.
20 patients of a metabolic ward received a six-hour infusion of sorbitol at a dosis of 0.125 g/kg/h(n equal to 10) and 0.25 g/kg/h(n equal to 10) body weight. Cholesterol levels showed a significant fall in both groups (p smaller than 0.05) and triglycerides rose significantly (p smaller than 0.05). The concentrations of acetoacetate and beta-hydroxybutyrate were lowered irrespective of the dosis. The cholesterol-reducing effect can be explained by the antiketogenic action, whereas the increase in triglycerides possibly could be the result of raised alpha-glycerophosphate.
代谢病房的20名患者接受了为期6小时的山梨醇输注,剂量分别为0.125 g/kg/h(n = 10)和0.25 g/kg/h(n = 10)体重。两组患者的胆固醇水平均显著下降(p < 0.05),甘油三酯显著升高(p < 0.05)。无论剂量如何,乙酰乙酸和β-羟基丁酸的浓度均降低。胆固醇降低作用可通过抗生酮作用来解释,而甘油三酯的升高可能是α-甘油磷酸升高的结果。