一名接受高效抗逆转录病毒治疗的艾滋病患者的微孢子虫性角膜结膜炎得到缓解。
Resolution of microsporidial keratoconjunctivitis in an AIDS patient treated with highly active antiretroviral therapy.
作者信息
Martins S A, Muccioli C, Belfort R, Castelo A
机构信息
Department of Ophthalmology, Federal University of São Paulo-Paulista School of Medicine, Rua Botucatu 824, São Paulo-SP, Brazil.
出版信息
Am J Ophthalmol. 2001 Mar;131(3):378-9. doi: 10.1016/s0002-9394(00)00810-2.
PURPOSE
To report the outcome of microsporidial keratoconjunctivitis in a patient with acquired immunodeficiency syndrome (AIDS) after highly active antiretroviral therapy without any specific treatment for microsporidiosis.
METHODS
Case report. A 42-year-old woman diagnosed with AIDS and severe immunodepression (CD4+ of 9 cells/mm(3) and viral load of 460,000/mm(3)), antiretroviral naive, presented with cerebral toxoplasmosis and microsporidial keratoconjunctivitis in the right eye documented by conjunctival scraping and electron microscopy.
RESULTS
The patient was treated with a combination of indinavir, stavudine, and lamivudine, besides sulfadiazine and pyrimethamine. No specific treatment for the microsporidial keratoconjunctivitis was attempted. One month later, the keratoconjunctivitis had disappeared.
CONCLUSION
This case suggests that microsporidial keratoconjunctivitis in the setting of AIDS and severe immunodepression can be effectively managed with highly active antiretroviral therapy alone.
目的
报告一名获得性免疫缺陷综合征（AIDS）患者在接受高效抗逆转录病毒治疗但未针对微孢子虫病进行任何特异性治疗后发生微孢子虫性角膜结膜炎的转归。
方法
病例报告。一名42岁女性，诊断为AIDS且免疫严重抑制（CD4+细胞计数为9个/mm³，病毒载量为460,000/mm³），初治患者，因脑弓形虫病及右眼微孢子虫性角膜结膜炎就诊，结膜刮片及电子显微镜检查确诊。
结果
患者接受茚地那韦、司他夫定和拉米夫定联合治疗，同时使用磺胺嘧啶和乙胺嘧啶。未尝试对微孢子虫性角膜结膜炎进行特异性治疗。1个月后，角膜结膜炎消失。
结论
该病例提示，在AIDS及严重免疫抑制情况下的微孢子虫性角膜结膜炎可仅通过高效抗逆转录病毒治疗得到有效控制。
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