Cortey A, Patkai J
Service de Néonatologie, Hôpital Intercommunal, 40, avenue de Verdun, 94010 Créteil Cedex.
J Gynecol Obstet Biol Reprod (Paris). 2001 Feb;30(1 Suppl):27-35.
With improvement of critical care of the newborn, perinatal mortality had decreased along the past decades. However, recent studies have shown that there is a slightly increase in the prevalence of cerebral palsy over the same period either for term or premature babies. Epidemiological data stress the multifactorial origins of cerebral palsy. Along with premature birth one of the predominant cause appears to be chorioamnionitis. Using data from a review of clinical and experimental studies the authors aim to clarify the link between infection, inflammation and fetal brain damage. The hypothesis that cytokines as mediators of inflammation can also mediate neurotoxicity is developed.
随着新生儿重症监护的改善，围产期死亡率在过去几十年中有所下降。然而，最近的研究表明，在同一时期，足月儿或早产儿的脑瘫患病率略有上升。流行病学数据强调脑瘫的多因素起源。除早产外，绒毛膜羊膜炎似乎是主要原因之一。作者利用临床和实验研究综述中的数据，旨在阐明感染、炎症与胎儿脑损伤之间的联系。提出了细胞因子作为炎症介质也可介导神经毒性的假说。
