Price M A, Tennant C C, Butow P N, Smith R C, Kennedy S J, Kossoff M B, Dunn S M
Department of Psychological Medicine, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Cancer. 2001 Feb 15;91(4):686-97.
The evidence supporting an association between life event stress and breast carcinoma development is inconsistent.
Five hundred fourteen women requiring biopsy after routine mammographic breast screening were interviewed using the Brown and Harris Life Event and Difficulties Schedule. Other psychosocial variables assessed included social support, emotional control, and defense style. Biopsy results identified 239 women with breast carcinoma and 275 women with benign breast disease. Multiple logistic regression analysis was used to distinguish between breast carcinoma subjects and benign breast disease controls based on these psychosocial variables and their interactions.
The findings of the current study revealed a significant interaction between highly threatening life stressors and social support. Women experiencing a stressor objectively rated as highly threatening and who were without intimate emotional social support had a ninefold increase in risk of developing breast carcinoma.
Although there was no evidence of an independent association between life event stress and breast carcinoma, the findings of the current study provided strong evidence that social support interacts with highly threatening life stressors to increase the risk of breast carcinoma significantly. [See also accompanying article on pages 679-85, this issue.]
支持生活事件压力与乳腺癌发生之间存在关联的证据并不一致。
使用布朗和哈里斯生活事件与困难量表对514名在常规乳房钼靶筛查后需要进行活检的女性进行了访谈。评估的其他心理社会变量包括社会支持、情绪控制和防御方式。活检结果确定了239名患有乳腺癌的女性和275名患有良性乳腺疾病的女性。基于这些心理社会变量及其相互作用，采用多元逻辑回归分析来区分乳腺癌患者和良性乳腺疾病对照者。
当前研究的结果显示，高度威胁性的生活应激源与社会支持之间存在显著的相互作用。经历客观上被评为高度威胁性应激源且没有亲密情感社会支持的女性患乳腺癌的风险增加了9倍。
尽管没有证据表明生活事件压力与乳腺癌之间存在独立关联，但当前研究的结果提供了有力证据，即社会支持与高度威胁性的生活应激源相互作用，显著增加了患乳腺癌的风险。[另见本期第679 - 85页的相关文章。]
