Nolan G R, Hirst L W, Bancroft B J
Division of Anatomical Pathology and Cytopathology, Queensland Health Pathology Service--Royal Brisbane Hospitals Campus, Queensland, Australia.
Cancer. 2001 Feb 25;93(1):60-7.
The term ocular surface squamous neoplasia (OSSN) encompasses conjunctival and corneal intraepithelial neoplasia through to invasive squamous cell carcinoma of the ocular surface. The disease is related to prolonged exposure to solar ultraviolet light and has been proposed as an acquired immune deficiency syndrome-associated tumor. To the authors' knowledge, very few reports describing the cytology of these lesions have been published.
Impression cytology (IC) samples collected from the eyes of patients with a range of ocular surface diseases were available for study. From these, 267 sets of impressions had subsequent histopathology that had been collected within 6 months of the IC, and which indicated the presence of OSSN. The IC from these cases was used to describe the cytomorphology of intraepithelial and invasive OSSN.
Within the intraepithelial group, keratinized dysplastic cells that often were accompanied by hyperkeratosis, syncytial-like groupings, and nonkeratinized dysplastic cells were described. Within the invasive group, cases with significant keratinization and an additional group of cases with little keratinization and sometimes also prominent macronucleoli were described. Keratinized cases were the most numerous in both the intraepithelial and invasive groups. A description also was given of a low number of cases with cytology and also subsequent histopathology indicating the presence of intraepithelial OSSN, in the absence of a clinically detectable lesion.
This detailed description of the cytomorphology of a high number of cases of OSSN with confirmation by histopathology should assist others with little experience of the cytology of these lesions to examine them with increased confidence. Cancer (Cancer Cytopathol)
眼表鳞状上皮肿瘤（OSSN）这一术语涵盖了结膜和角膜上皮内瘤变直至眼表浸润性鳞状细胞癌。该疾病与长期暴露于太阳紫外线有关，并且被认为是一种与获得性免疫缺陷综合征相关的肿瘤。据作者所知，很少有关于这些病变细胞学的报道发表。
从患有一系列眼表疾病的患者眼中收集的印片细胞学（IC）样本可供研究。其中，267套印片随后进行了组织病理学检查，这些检查是在IC检查后的6个月内进行的，结果显示存在OSSN。这些病例的IC用于描述上皮内和浸润性OSSN的细胞形态。
在上皮内组中，描述了经常伴有角化过度、合体样聚集的角化发育异常细胞以及非角化发育异常细胞。在浸润组中，描述了有显著角化的病例以及另一组角化较少且有时也有明显大核仁的病例。角化病例在上皮内组和浸润组中都是最多的。还描述了少数细胞学及随后组织病理学显示存在上皮内OSSN但临床上未检测到病变的病例。
对大量经组织病理学证实的OSSN病例的细胞形态进行的详细描述，应有助于那些对这些病变细胞学经验较少的人更有信心地对其进行检查。《癌症（癌症细胞病理学）》
