Foote J A, Harris R B, Giuliano A R, Roe D J, Moon T E, Cartmel B, Alberts D S
Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Int J Cancer. 2001 Jan 20;95(1):7-11. doi: 10.1002/1097-0215(20010120)95:1<7::aid-ijc1001>3.0.co;2-x.
Risk factors for non-melanoma skin cancer among populations with evidence of precursor damage are not well described. We examined and compared risk factors associated with the development of cutaneous basal-cell (BCC) or squamous-cell (SCC) carcinoma among a group of 918 adults with significant sun damage (> or = 10 clinically assessable actinic keratoses) but no prior history of skin cancer. These adults were participants in a 5-year skin chemoprevention trial between 1985 and 1992, who had been randomized to the placebo group and followed for occurrence of skin cancer. During the study, a total of 129 first SCC and 164 first BCC lesions were diagnosed. The overall BCC and SCC incidence rates for this group of men and women, mean age 61 years, were 4,106 and 3,198 per 100,000 person-years, respectively. Different constitutional and exposure factors were independently associated with BCC compared to SCC. Only increased age independently predicted BCC occurrence among this population. In contrast, older age along with male gender, natural red hair color and adult residence in Arizona for 10 or more years independently predicted SCC occurrence. The substantial incidence of skin cancer found among this population confirms the need for active dermatological monitoring among individuals with multiple visible actinic lesions.
有前驱损伤证据的人群中非黑素瘤皮肤癌的风险因素尚未得到充分描述。我们在一组918名有明显晒伤（≥10个临床可评估的光化性角化病）但无皮肤癌病史的成年人中，研究并比较了与皮肤基底细胞癌（BCC）或鳞状细胞癌（SCC）发生相关的风险因素。这些成年人是1985年至1992年期间一项为期5年的皮肤化学预防试验的参与者，他们被随机分配到安慰剂组，并随访皮肤癌的发生情况。在研究期间，共诊断出129例原发性SCC和164例原发性BCC病变。这组平均年龄为61岁的男性和女性的总体BCC和SCC发病率分别为每100,000人年4,106例和3,198例。与SCC相比，不同的体质和暴露因素与BCC独立相关。在该人群中，只有年龄增加独立预测BCC的发生。相比之下，年龄较大以及男性、天生红发和在亚利桑那州居住10年或更长时间的成年人独立预测SCC的发生。在该人群中发现的皮肤癌高发病率证实了对有多个可见光化性病变的个体进行积极皮肤科监测的必要性。
