Goldberg D J, Samady J A
Division of Dermatology, New Jersey Medical School, Newark, New Jersey 07103, USA.
Lasers Surg Med. 2001;28(2):141-4. doi: 10.1002/lsm.1029.
The aim of this study was to evaluate the efficacy and safety of the intense pulsed light source (IPL) and the Nd:YAG laser in the treatment of facial rhytids. Both systems can be used in a non-ablative manner and cause a dermal wound. This is thought to stimulate the production of new collagen without epidermal disruption. Non-ablative techniques eliminate the downtime that must be endured by patients treated with ablative methods such as the carbon dioxide and erbium lasers.
STUDY DESIGN/MATERIALS AND METHODS: Fifteen subjects with perioral rhytids and Fitzpatrick skin types II and III received three-to-five treatments with the IPL using 590 and 755 nm cut-off filters, and the 1,064-nm Nd:YAG laser. The subjects were evaluated at 2, 4, 8, 12, and 24 weeks after the final treatment for improvement in rhytids and presence of any side effects.
At 6 months, the patient satisfaction score (1-10) was comparable in all three groups. Evaluator assessment of improved skin quality was also similar in all three treatment groups. Side effects such as blistering and erythema were most commonly seen in the subjects treated with the IPL. The least discomfort was seen with the Nd:YAG laser.
Although both non-ablative treatment systems improved facial rhytids presumably by causing a non-specific dermal wound, the Nd:YAG laser was better tolerated and produced fewer side effects.
本研究旨在评估强脉冲光源（IPL）和钕钇铝石榴石激光（Nd:YAG激光）治疗面部皱纹的疗效与安全性。这两种系统均可采用非剥脱方式使用并造成真皮损伤。据认为，这会刺激新胶原蛋白的生成而不破坏表皮。非剥脱技术消除了使用剥脱性方法（如二氧化碳激光和铒激光）治疗的患者必须忍受的停工期。
研究设计/材料与方法：15名患有口周皱纹且皮肤类型为菲茨帕特里克II型和III型的受试者接受了3至5次使用590纳米和755纳米截止滤光片的IPL治疗以及1064纳米的Nd:YAG激光治疗。在最后一次治疗后的2周、4周、8周、12周和24周对受试者进行评估，以观察皱纹改善情况及是否存在任何副作用。
在6个月时，所有三组患者的满意度评分（1至10分）相当。所有三个治疗组的评估者对皮肤质量改善的评估也相似。水泡和红斑等副作用在接受IPL治疗的受试者中最为常见。Nd:YAG激光引起的不适最少。
尽管两种非剥脱治疗系统可能通过造成非特异性真皮损伤改善了面部皱纹，但Nd:YAG激光的耐受性更好，产生的副作用更少。
