Lipper Graeme M, Perez Maritza
Advanced Dermcare, Danbury, Connecticut 06811, USA.
Dermatol Surg. 2006 Aug;32(8):998-1006. doi: 10.1111/j.1524-4725.2006.32222.x.
Effective treatment of facial acne scarring presents a major challenge. Nonablative lasers and radiofrequency devices work by thermally stimulating dermal collagen remodeling, thereby softening acne scars in a minimally invasive fashion. One such laser, a 1,064-nm short-pulsed Nd:YAG, uses rapidly scanned low-energy infrared pulses to heat the dermis selectively through the normal dermal microvasculature.
In this pilot study, the safety and efficacy of a novel short-pulsed Nd:YAG laser were investigated for the treatment of moderate to severe facial acne scarring.
Nine of 10 enrolled patients with moderate to severe facial acne scarring received eight sequential 1,064-nm Nd:YAG treatments (laser parameters 14 J/cm2, 0.3 milliseconds, 5-mm spot size, 7-Hz pulse rate, 2,000 pulses per side of face). Patients were graded for the presence and severity of three scar morphologies: superficial (rolling), medium-depth (boxcar), and deep (ice pick). Outcome measures included blinded evaluation of before and after photographs by three physician observers (scar severity score) and patient self-assessment.
Acne scarring improved in 100% of the nine patients completing the study. Scar severity scores improved by a mean of 29.36% (95% confidence interval, 16.93%-41.79%; p = .006); 89% of patients noted greater than 10% scar improvement. No treatment-related adverse events were seen.
Our findings support the use of a short-pulsed, low-fluence 1,064-nm Nd:YAG laser as a safe, effective treatment for facial acne scarring. Scar improvement was noted in all treated subjects with minimal discomfort and no downtime. This protocol appears to be most effective at reducing scar depth and softening scar contours. A laser upgrade needed for the study was provided to the authors at a reduced price.
面部痤疮瘢痕的有效治疗是一项重大挑战。非剥脱性激光和射频设备通过热刺激真皮胶原重塑发挥作用,从而以微创方式软化痤疮瘢痕。一种这样的激光,即1064纳米短脉冲Nd:YAG激光,利用快速扫描的低能量红外脉冲通过正常的真皮微血管系统选择性地加热真皮。
在这项初步研究中,研究了一种新型短脉冲Nd:YAG激光治疗中度至重度面部痤疮瘢痕的安全性和有效性。
10名入选的中度至重度面部痤疮瘢痕患者中有9名接受了8次连续的1064纳米Nd:YAG治疗(激光参数:14 J/cm²、0.3毫秒、5毫米光斑大小、7赫兹脉冲频率、每侧面部2000个脉冲)。对患者的三种瘢痕形态(浅表性(滚动性)、中等深度(箱车型)和深部(冰锥型))的存在情况和严重程度进行分级。结果指标包括由三名医生观察者对治疗前后照片进行盲法评估(瘢痕严重程度评分)以及患者自我评估。
完成研究的9名患者中100%的痤疮瘢痕得到改善。瘢痕严重程度评分平均改善了29.36%(95%置信区间,16.93%-41.79%;p = 0.006);89%的患者瘢痕改善超过10%。未观察到与治疗相关的不良事件。
我们的研究结果支持使用短脉冲、低能量密度的1064纳米Nd:YAG激光作为面部痤疮瘢痕的安全、有效治疗方法。所有接受治疗的受试者瘢痕均有改善,不适轻微且无需停工。该方案似乎在减少瘢痕深度和软化瘢痕轮廓方面最为有效。研究所需的激光设备以优惠价格提供给了作者。