Murakami Hiroya, Noda Sumiyo, Okamura Yukiyasu, Sakakibara Takumi, Ishikawa Tadao, Nakamura Hajime, Yaguchi Toyohisa, Harada Akio
Dept. of Surgery, Kainan Hospital.
Gan To Kagaku Ryoho. 2002 Nov;29(11):1963-6.
A 64-year-old woman underwent muscle-preserving mastectomy for breast cancer in April 1999. She developed multiple lung metastases 3 months later. The metastases partially responded to 10 cycles of CAF (cyclophosphamide, adriamycin, 5-fluorouracil). However, her lung metastases worsened again 7 months later and CAF was not effective (progressive disease). We therefore began administration of low-dose paclitaxel (80 mg/m2/week) and high-dose toremifene (120 mg/day) alternately in April 2001. This alternative therapy brought a marked decrease in the lung metastases. After 4 cycles of this treatment, lung metastatic findings had disappeared from her chest X-ray. This alternative therapy is potentially effective against metastatic breast cancer.
一名64岁女性于1999年4月因乳腺癌接受了保留肌肉的乳房切除术。3个月后她出现了多处肺转移。这些转移灶对10个周期的CAF（环磷酰胺、阿霉素、5-氟尿嘧啶）治疗部分有效。然而，7个月后她的肺转移灶再次恶化，且CAF治疗无效（疾病进展）。因此，我们于2001年4月开始交替给予低剂量紫杉醇（80mg/m²/周）和高剂量托瑞米芬（120mg/天）。这种交替疗法使肺转移灶明显减少。经过4个周期的这种治疗后，她胸部X光片上的肺转移征象已消失。这种交替疗法对转移性乳腺癌可能有效。
