Lu D, Duvic M, Medeiros L J, Luthra R, Dorfman D M, Jones D
Division of Pathology and Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Houston, USA.
Am J Clin Pathol. 2001 Mar;115(3):413-21. doi: 10.1309/3N7P-J84L-JQ9K-G89R.
Three chemokines, Mig, IP-10, and I-TAC, are expressed highly in the epidermis. We examined the expression of the receptor for these chemokines, CXCR3, in cutaneous T-cell lymphoma. We compared CXCR3 expression with that of cutaneous lymphocyte antigen (CLA) and the activation marker CD30. CXCR3 was expressed by at least a subset of tumor lymphocytes in all 25 cases of low-grade mycosis fungoides (MF), with most cells positive in 20 cases. In progressed or transformed MF, CXCR3 expression was noted in 5 of 22 cases. In 4 of 5 MF cases with sequential biopsy specimens, large cell transformation was accompanied by loss of CXCR3 expression. In contrast, CLA was expressed in 35 of 42 MF cases with no significant differences in expression level between low-grade and transformed cases. In other lymphomas, CXCR3 was expressed in 4 of 4 cases of lymphomatoid papulosis, 3 of 4 cases of CD8+ cutaneous T-cell lymphoma, and 3 of 6 cases of systemic T-cell lymphoma in skin, but not in 10 cases of cutaneous anaplastic large cell lymphoma. CXCR3 expression was associated with epidermotropic T-cell tumors but was largely absent in dermal-based tumors. This phenotypic change likely influences the loss of epidermal localization.
三种趋化因子，即Mig、IP - 10和I - TAC，在表皮中高表达。我们检测了这些趋化因子的受体CXCR3在皮肤T细胞淋巴瘤中的表达。我们将CXCR3的表达与皮肤淋巴细胞抗原（CLA）和活化标志物CD30的表达进行了比较。在所有25例低级蕈样肉芽肿（MF）中，至少有一部分肿瘤淋巴细胞表达CXCR3，其中20例大多数细胞呈阳性。在进展期或转化型MF中，22例中有5例检测到CXCR3表达。在5例有连续活检标本的MF病例中，有4例大细胞转化伴随着CXCR3表达的缺失。相比之下，42例MF病例中有35例表达CLA，低级和转化型病例之间的表达水平无显著差异。在其他淋巴瘤中，淋巴瘤样丘疹病4例中有4例表达CXCR3，CD8 + 皮肤T细胞淋巴瘤4例中有3例表达，皮肤系统性T细胞淋巴瘤6例中有3例表达，但10例皮肤间变性大细胞淋巴瘤均未表达。CXCR3表达与亲表皮性T细胞肿瘤相关，但在真皮性肿瘤中大多不存在。这种表型变化可能影响表皮定位的丧失。
