Saulite Ieva, Hoetzenecker Wolfram, Weidinger Stephan, Cozzio Antonio, Guenova Emmanuella, Wehkamp Ulrike
Department of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland; Department of Infectology and Dermatology, Riga Stradins University, Riga, Latvia.
Department of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland.
Biomed Res Int. 2016;2016:9717530. doi: 10.1155/2016/9717530. Epub 2016 May 17.
Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.
Sézary综合征（SS）是一种侵袭性红皮病型瘙痒性皮肤T细胞淋巴瘤（CTCL），从免疫学角度来看，其特征为Th2细胞因子水平升高、血清IgE升高以及细胞免疫受损。SS不仅临床表现，而且其标志性免疫学特征通常与特应性皮炎（AD）（一种常见的良性慢性炎症性皮肤病）的急性发作有惊人的相似之处。鉴于几种免疫学特征的重叠，在这两种疾病的某些阶段应用相似甚至相同的治疗方法可能会被考虑。本综述的目的是比较目前公认的AD和SS的免疫学方面以及可能的治疗靶点。
