Comín-Colet J, Sánchez-Corral M A, Alegre-Sancho J J, Valverde J, López-Gómez D, Sabaté X, Juan-Mas A, Esplugas E
Department of Cardiology, Hospital Prínceps d'Espanya, Ciutat Sanitária i Universitária de Bellvitge, Barcelona, Spain.
Lupus. 2001;10(1):59-62. doi: 10.1191/096120301673172543.
Complete heart block (CHB) is a rare complication of systemic lupus erythematosus (SLE), mainly seen during an acute flare-up of the disease or after high-dose long-term treatment with antimalarial drugs, although anti-Ro and anti-RNP antibodies have also been implied by some authors. A 40-y-old woman developed CHB in the context of an acute flare-up of SLE, first diagnosed three years ago, having recently commenced hydroxychloroquine (HCQ) treatment. Anti-Ro and anti-RNP antibodies were also positive. No features of myocarditis were found. A temporary pacemaker was required and complete resolution was achieved on steroid therapy with withdrawal of antimalarial therapy. The characteristics of previous cases are well publicised and discussion focuses on the possible aetiology and pathogenesis of the present case.
完全性心脏传导阻滞（CHB）是系统性红斑狼疮（SLE）的一种罕见并发症，主要见于疾病急性发作期或长期大剂量使用抗疟药治疗后，不过一些作者也指出抗Ro和抗RNP抗体也与之有关。一名40岁女性在SLE急性发作时出现CHB，该患者三年前首次确诊SLE，近期开始使用羟氯喹（HCQ）治疗。抗Ro和抗RNP抗体也呈阳性。未发现心肌炎特征。需要植入临时起搏器，停用抗疟药并给予类固醇治疗后完全恢复。以往病例的特征已广为人知，讨论聚焦于本例可能的病因和发病机制。
