Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 570 South Preston St, Baxter Research Building I, Room 204E, Louisville, KY 40202, USA.
Arthritis Res Ther. 2012 Feb 20;14(1):204. doi: 10.1186/ar3701.
Systematic lupus erythematosus (SLE) is a complex disease for which molecular diagnostics are limited and pathogenesis is not clearly understood. Important information is provided in this regard by identification and characterization of more specific molecular and cellular targets in SLE immune cells and target tissue and markers of early-onset and effective response to treatment of SLE complications. In recent years, advances in proteomic technologies and applications have facilitated such discoveries. Here we provide a review of insights into SLE pathogenesis, diagnosis and treatment that have been provided by mass spectrometry-based proteomic approaches.
系统性红斑狼疮（SLE）是一种复杂的疾病，其分子诊断方法有限，发病机制尚不清楚。通过鉴定和描述 SLE 免疫细胞和靶组织中更具特异性的分子和细胞靶点，以及 SLE 并发症早期发生和治疗有效反应的标志物，为我们提供了重要信息。近年来，蛋白质组学技术及其应用的进步促进了这些发现。本文综述了基于质谱的蛋白质组学方法在 SLE 发病机制、诊断和治疗方面的研究进展。
