Jasani B, Cristaudo A, Emri S A, Gazdar A F, Gibbs A, Krynska B, Miller C, Mutti L, Radu C, Tognon M, Procopio A
Immunocytochemistry and Molecular Pathology Unit, Department of Pathology, University of Wales College of Medicine, CF14 4XN, Cardiff, UK.
Semin Cancer Biol. 2001 Feb;11(1):49-61. doi: 10.1006/scbi.2000.0346.
SV40 was discovered as a contaminant of poliovirus vaccines that were inadvertently administered to millions of people in Europe and the United States between 1955 and 1963. Shortly afterwards, SV40 was proven to be oncogenic in rodents and capable of transforming human and animal cells in vitro. The possibility that SV40 might cause tumours in humans thus became a subject of scientific and public interest and scrutiny. However, largely due to a lack of significant epidemiological evidence, interest in assessing SV40's potential carcinogenic role in humans diminished. Recently, many laboratories have reported the presence of SV40-like DNA in a high proportion of human mesotheliomas, ependymomas and osteosarcoma (the three main types of tumours caused by virus in hamsters), renewing the question whether SV40 might be a human tumour virus. Molecular data from these studies are reviewed to re-evaluate the potential role of SV40 as a human carcinogen.
SV40是作为脊髓灰质炎病毒疫苗的污染物被发现的，在1955年至1963年间，数百万欧洲和美国民众无意中接种了这些疫苗。不久之后，SV40被证明在啮齿动物中具有致癌性，并且能够在体外转化人类和动物细胞。因此，SV40可能导致人类肿瘤的可能性成为科学和公众关注及审查的主题。然而，很大程度上由于缺乏重要的流行病学证据，评估SV40在人类中潜在致癌作用的兴趣减弱了。最近，许多实验室报告在高比例的人类间皮瘤、室管膜瘤和骨肉瘤（仓鼠中由病毒引起的三种主要肿瘤类型）中存在SV40样DNA，这再次引发了SV40是否可能是一种人类肿瘤病毒的问题。对这些研究的分子数据进行了综述，以重新评估SV40作为人类致癌物的潜在作用。
