用大环内酯类抗生素成功治疗色素性痒疹。

The successful treatment of prurigo pigmentosa with macrolide antibiotics.

作者信息

Yazawa N, Ihn H, Yamane K, Etoh T, Tamaki K

机构信息

Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Dermatology. 2001;202(1):67-9. doi: 10.1159/000051591.

DOI:10.1159/000051591

PMID:11244235

Abstract

Recent studies have demonstrated that macrolide antibiotics have anti-inflammatory as well as antibacterial effects. Therefore, macrolide antibiotics have been successfully used to treat patients with various inflammatory diseases. We evaluated the effect of macrolide antibiotics in 4 patients with prurigo pigmentosa who were treated with either 400 mg of clarithromycin or 300 mg of roxythromycin daily. Eruption and pruritus disappeared within a week in all the patients while those symptoms were unresponsive to other drugs. Although the mechanism of this effect remains unclear in patients with prurigo pigmentosa, macrolide antibiotics can be considered as an alternative treatment for prurigo pigmentosa.

摘要

最近的研究表明，大环内酯类抗生素具有抗炎和抗菌作用。因此，大环内酯类抗生素已成功用于治疗各种炎症性疾病的患者。我们评估了大环内酯类抗生素对4例色素性痒疹患者的疗效，这些患者每天分别接受400毫克克拉霉素或300毫克罗红霉素治疗。所有患者的皮疹和瘙痒在一周内消失，而这些症状对其他药物无反应。尽管色素性痒疹患者这种作用的机制尚不清楚，但大环内酯类抗生素可被视为色素性痒疹的一种替代治疗方法。