维持性血液透析患者中一种新型DNA病毒（TTV）的流行情况。

Prevalence of a novel DNA virus (TTV) among patients on maintenance hemodialysis.

作者信息

Schröter M, Feucht H H, Zöllner B, Schäfer P, Laufs R

机构信息

Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Hamburg, Deutschland.

出版信息

Nephron. 2001 Feb;87(2):139-42. doi: 10.1159/000045902.

DOI:10.1159/000045902

PMID:11244308

Abstract

BACKGROUND/AIMS: A recently detected DNA virus (TTV) has been assumed to be responsible for posttransfusion hepatitis in humans. Until now it is unclear whether patients on maintenance hemodialysis are at increased risk of acquiring TTV.

METHODS

Serum samples derived from 143 chronically hemodialyzed patients were examined for TTV viremia by nested PCR. All serum specimens were also investigated for viremia and for the presence of antibodies of hepatitis C virus (HCV) and GB virus C/hepatitis G virus (GBV-C/HGV) by PCR and serological assays, respectively.

RESULTS

The prevalence of TTV was determined to be 18.8% (n = 27), for HCV a prevalence of 15.4% (n = 22) and for GBV-C/HGV of 8.4% (n = 12) could be demonstrated. Parallel infection by TTV and HCV was detected in only 1.4% (n = 2) of the patients. In no serum sample could TTV and GBV-C/HGV be detected in parallel. None of the solely TTV-viremic individuals had clinical or biochemical signs of liver disease.

CONCLUSION

From our data we conclude that TTV viremia is widespread among hemodialysis patients and can be detected in 18.8%. Since no viremic patient had clinical or biochemical signs of liver disease, the hepatitis-inducing capacity of TTV remains unclear.

摘要

背景/目的：最近发现的一种DNA病毒（TTV）被认为与人类输血后肝炎有关。目前尚不清楚维持性血液透析患者感染TTV的风险是否增加。

方法

采用巢式PCR检测143例慢性血液透析患者血清样本中的TTV病毒血症。所有血清标本还分别通过PCR和血清学检测，检测病毒血症以及丙型肝炎病毒（HCV）和GB病毒C/庚型肝炎病毒（GBV-C/HGV）抗体的存在情况。

结果

TTV的患病率为18.8%（n = 27），HCV的患病率为15.4%（n = 22），GBV-C/HGV的患病率为8.4%（n = 12）。仅1.4%（n = 2）的患者检测到TTV和HCV的合并感染。在任何血清样本中均未检测到TTV和GBV-C/HGV的合并感染。仅TTV病毒血症的个体均无肝病的临床或生化体征。