Badia L, Lund V J
Professorial Unit, Institute of Laryngology and Otology, Royal National Throat, Nose and Ear Hospital, London, UK.
J Laryngol Otol. 2001 Mar;115(3):220-2. doi: 10.1258/0022215011907028.
Respiratory scleroma (often termed 'rhinoscleroma') is a chronic inflammatory condition in which deforming masses of tissue distend the nasal cavity. Klebsiella rhinoscleromatis is the causative agent of this infection and the Mikulicz cell is specific to the lesion being a large macrophage with clear cytoplasm containing the bacilli. Antibiotic therapy has traditionally consisted of streptomycin and tetracycline long-term but this presents problems with adverse side-effects and poor patient compliance. We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin. As mentioned in a review of patients with rhinoscleroma at the Mayo clinic in 1993, the fluoroquinolones deserve further study as potentially highly effective agents for this condition. Ciprofloxacin is convenient for oral administration and has few adverse effects. It achieves good tissue penetration, is concentrated in macrophages and may prove to be useful in the therapy of rhinoscleroma.
呼吸道硬结病（通常称为“鼻硬结病”）是一种慢性炎症性疾病，其中变形的组织块会使鼻腔扩张。鼻硬结克雷伯菌是这种感染的病原体，米库利奇细胞是该病变特有的，是一种含有杆菌的、细胞质清晰的大巨噬细胞。传统上，抗生素治疗一直是长期使用链霉素和四环素，但这会带来副作用和患者依从性差的问题。我们报告了一名患有鼻硬结病的年轻患者，口服环丙沙星治疗后病情得到缓解。正如1993年梅奥诊所对硬结病患者的综述中所提到的，氟喹诺酮类药物作为治疗这种疾病的潜在高效药物值得进一步研究。环丙沙星便于口服且副作用少。它能很好地穿透组织，在巨噬细胞中聚集，可能被证明对硬结病的治疗有用。
