Xiang F, Niu Z, Yang M
Department of Pathology, Qingdao University Medical College, Qingdao, Shandong 266021.
Zhonghua Bing Li Xue Za Zhi. 1998 Oct;27(5):333-6.
To study the relationship between expression of laminin (LN), fibronectin (FN), collagen IV (Col. IV) and clinical pathology of primary lung cancer.
LSAB method was used to detect the expression of LN, FN and Col. IV in 184 cases of lung carcinoma.
Expression of LN and Col. IV in well and moderately differentiated pulmonary squamous cell carcinoma were both higher than that in poorly differentiated cases (P < 0.01), and marked difference was found between lymph node positive and negative cases (P < 0.05). Obvious difference in the expression of LN and Col. IV was found between the patient groups with squamous cell carcinoma who died within 1/2 year and those surviving more than 5 years (P < 0.01), as was the difference in expression of FN (P < 0.05). Obvious difference in the expression of FN and Col. IV was found between patients groups with adenocarcinoma who died within 1/2 year and those surviving more than 5 years (P < 0.05, 0.01).
The expression of LN and Col. IV correlated with histological grading and lymph node metastasis of pulmonary squamous cell carcinoma; LN, FN, Col. IV can also be regarded as a parameter for evaluating prognosis of pulmonary squamous cell carcinoma. The expression of FN and Col. IV can be regarded as a parameter for evaluating the prognosis of pulmonary adenocarcinoma.
研究层粘连蛋白（LN）、纤连蛋白（FN）、IV型胶原（Col.IV）的表达与原发性肺癌临床病理之间的关系。
采用LSAB法检测184例肺癌组织中LN、FN和Col.IV的表达。
肺高、中分化鳞状细胞癌中LN和Col.IV的表达均高于低分化病例（P<0.01），且淋巴结阳性与阴性病例之间存在显著差异（P<0.05）。肺鳞状细胞癌患者中，半年内死亡者与存活5年以上者之间，LN和Col.IV的表达存在明显差异（P<0.01），FN的表达也有差异（P<0.05）。肺腺癌患者中，半年内死亡者与存活5年以上者之间，FN和Col.IV的表达存在明显差异（P<0.05，0.01）。
LN和Col.IV的表达与肺鳞状细胞癌的组织学分级及淋巴结转移相关；LN、FN、Col.IV也可作为评估肺鳞状细胞癌预后的指标。FN和Col.IV的表达可作为评估肺腺癌预后的指标。
