Bregazzi V S, LaRue S M, Powers B E, Fettman M J, Ogilvie G K, Withrow S J
Department of Clinical Science, College of Veterinary Medicine, Colorado State University, Fort Collins 80523, USA.
Vet Radiol Ultrasound. 2001 Jan-Feb;42(1):77-9. doi: 10.1111/j.1740-8261.2001.tb00907.x.
Seven cats with advanced oral squamous cell carcinoma were treated with palliative radiotherapy. Megavoltage radiation in 8 Gray (Gy) fractions was delivered on days 0, 7, and 21 for a total dose of 24 Gy. Treatment field included the mandible, oropharynx, retropharyngeal lymph nodes, and tonsils. Adjuvant treatment with chemotherapy was variable. Age ranged from 13 to 18 years old with a median age of 15 years. Three of the seven cats (43%) did not complete treatment. Six cats were euthanized due to tumor growth and/or radiation side effects with a median survival time of 60 days (range = 42 to 97 days, mean = 63 +/- 8.4 days). Radiotherapy complications or progression of disease occurred in 6 of 7 (85.7 %) cats and included adverse clinical signs, such as mucositis, serosanguinous oral discharge, pain, and dysphagia. These data suggest that coarse fractionation radiotherapy did not result in palliation in cats with inoperable oral squamous cell carcinoma.
七只患有晚期口腔鳞状细胞癌的猫接受了姑息性放疗。在第0、7和21天给予8格雷（Gy）分次的兆伏级放疗，总剂量为24 Gy。治疗范围包括下颌骨、口咽、咽后淋巴结和扁桃体。化疗辅助治疗情况不一。年龄范围为13至18岁，中位年龄为15岁。七只猫中有三只（43%）未完成治疗。六只猫因肿瘤生长和/或放疗副作用而实施安乐死，中位生存时间为60天（范围=42至97天，平均=63±8.4天）。7只猫中有6只（85.7%）出现放疗并发症或疾病进展，包括黏膜炎、血性口腔分泌物、疼痛和吞咽困难等不良临床症状。这些数据表明，大分割放疗对无法手术的口腔鳞状细胞癌猫并未起到姑息作用。
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