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[超分割放射疗法治疗犬猫恶性黑色素瘤和鳞状细胞癌]

[Hypofractionated radiation therapy for the treatment of malignant melanoma and squamous cell carcinoma in dogs and cats].

作者信息

Kinzel Sylvia, Hein Sven, Stopinski Thaddeus, Koch Johannes, Buecker Arno, Treusacher Hans-Peter, Schmachtenberg Axel, Jansen Thomas, Eble Michael, Küpper Wernen

机构信息

Institut für Versuchstierkunde, Universitätsklinikums Aachen.

出版信息

Berl Munch Tierarztl Wochenschr. 2003 Mar-Apr;116(3-4):134-8.

Abstract

This study describes the experience with hypofractionated radiation therapy of squamous cell carcinoma and melanoma in dogs and cats. A total dose of 32-48 Gray (Gy) was delivered once a week in 8 Gy fractions. 34 animals in which a complete surgical excision was impossible were treated. There was no tumor detectable macroscopically in 14 patients at the beginning of radiation therapy. In 20 animals the median volume of the tumor was 9.9 cm3. The median survival times and the local tumor control of squamous cell carcinoma of the oral and nasal cavities and of the body are comparable to results which were reached with a Monday-Wednesday-Friday scheme. For the treatment of Melanoma the hypofractionated radiation therapy is first choice. There are no significant side effects. Late side effects did not occur. 88% of the owners are satisfied with this kind of treatment and would choose it again.

摘要

本研究描述了犬猫鳞状细胞癌和黑色素瘤的大分割放射治疗经验。总剂量32 - 48格雷(Gy),每周一次,每次8 Gy分割剂量。对34只无法进行完整手术切除的动物进行了治疗。放疗开始时,14只动物肉眼不可见肿瘤。20只动物的肿瘤中位体积为9.9立方厘米。口腔、鼻腔和身体鳞状细胞癌的中位生存时间和局部肿瘤控制情况与周一至周三至周五方案所取得的结果相当。对于黑色素瘤的治疗,大分割放射治疗是首选。没有明显的副作用。未出现晚期副作用。88%的主人对这种治疗方法满意,愿意再次选择。

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