Webb C P, Vande Woude G F
Van Andel Research Institute, Grand Rapids, MI 49503, USA.
J Neurooncol. 2000 Oct-Nov;50(1-2):71-87. doi: 10.1023/a:1006466605356.
Genetic instability and an accumulation of genetic and epigenetic changes during tumor progression lead to an increasingly aggressive and treatment-resistant phenotype, and ultimately metastasis. In recent years it has become well established that angiogenesis, the process by which new vasculature is formed from pre-existing vessels, is an essential component to primary tumor growth and distant metastasis. A greater understanding of the complex multitude of factors involved in tumor angiogenesis and metastasis is fundamental to the development of potential therapeutics to treat malignant disease. As highlighted throughout this review, angiogenesis and metastasis share many common cellular and molecular features. We will briefly discuss the pertinent genes involved in the regulation of angiogenesis and metastasis.
肿瘤进展过程中的基因不稳定以及基因和表观遗传变化的积累会导致肿瘤表型越来越具侵袭性且对治疗产生抗性，最终发生转移。近年来，血管生成（即从已有的血管形成新血管的过程）已被确认为原发性肿瘤生长和远处转移的重要组成部分。更深入了解肿瘤血管生成和转移所涉及的众多复杂因素，对于开发治疗恶性疾病的潜在疗法至关重要。正如本综述所强调的，血管生成和转移具有许多共同的细胞和分子特征。我们将简要讨论参与血管生成和转移调控的相关基因。
