Maddocks J L
Thorax. 1975 Feb;30(1):68-71. doi: 10.1136/thx.30.1.68.
The absorption of ampicillin from the lungs after intratracheal administration was studied in a healthy human. Doses of 50 mg, 250 mg, and 1,250 mg were given by intratracheal injection, and absorption of ampicillin from the lungs was assessed by measuring plasma levels, the area under the plasma level-time curve, and urinary excretion. All these indices of absorption increased with the dose of ampicillin. An intratracheal dose of 100 mg of probenecid together with 250 mg of ampicillin failed to reduce the absorption of ampicillin from the lungs. The uptake of ampicillin by human foetal bronchial slices in vitro was also studied; although viable, they did not accumulate ampicillin. These preliminary results suggest that ampicillin is absorbed from the lungs by passive diffusion.
在一名健康人体中研究了气管内给药后氨苄西林从肺部的吸收情况。通过气管内注射给予50毫克、250毫克和1250毫克的剂量，并通过测量血浆水平、血浆水平-时间曲线下面积和尿排泄来评估氨苄西林从肺部的吸收情况。所有这些吸收指标均随氨苄西林剂量的增加而增加。气管内给予100毫克丙磺舒与250毫克氨苄西林一起未能降低氨苄西林从肺部的吸收。还研究了人胎儿支气管切片在体外对氨苄西林的摄取；尽管切片有活力，但它们并未蓄积氨苄西林。这些初步结果表明，氨苄西林通过被动扩散从肺部吸收。
