丙磺舒对氨苄西林在人体胆汁中排泄的影响。
Effect of probenecid on the excretion of ampicillin in human bile.
作者信息
Kampmann J, Lindahl F, Hansen J M, Siersbaek-Nielsen K
出版信息
Br J Pharmacol. 1973 Apr;47(4):782-6. doi: 10.1111/j.1476-5381.1973.tb08205.x.
Abstract
- Ampicillin concentrations were determined in serum and bile after intravenous injection into patients with T-tube bile drainage of 1 gram ampicillin before and during probenecid medication. The concentrations were followed up to fifteen hours after injection.2. Probenecid increased the half-life of ampicillin in serum from 74 minutes to 137 minutes.3. Ampicillin concentrations in bile were higher following probenecid medication and a concentration over 5 mug/ml was obtained for 3 h longer than before probenecid.4. The ampicillin concentrations in bile were approximately the same as those in serum both before and during probenecid medication suggesting passive transport of ampicillin from blood to bile.5. A combined treatment of ampicillin and probenecid might be of clinical value in the therapy of cholangitis and typhoid carriers.
摘要
对行T管胆汁引流的患者静脉注射1克氨苄西林，在丙磺舒用药前及用药期间测定血清和胆汁中的氨苄西林浓度，并在注射后持续监测15小时。
丙磺舒使血清中氨苄西林的半衰期从74分钟延长至137分钟。
丙磺舒用药后胆汁中氨苄西林浓度更高，且浓度超过5微克/毫升的时间比丙磺舒用药前延长了3小时。
丙磺舒用药前及用药期间，胆汁中的氨苄西林浓度与血清中的大致相同，提示氨苄西林从血液到胆汁的被动转运。
氨苄西林与丙磺舒联合治疗可能对胆管炎和伤寒带菌者的治疗具有临床价值。
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本文引用的文献
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AMPICILLIN LEVELS IN HUMAN BILE.人体胆汁中的氨苄青霉素水平。
Br J Pharmacol Chemother. 1965 Feb;24(1):189-93. doi: 10.1111/j.1476-5381.1965.tb02094.x.
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Ampicillin activity in vitro and absorption and excretion in normal young men.氨苄西林在体外的活性以及在正常年轻男性体内的吸收与排泄。
Am J Med Sci. 1963 May;245:544-55.
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Ampicillin levels in human bile in the presence of biliary tract disease.存在胆道疾病时人体胆汁中的氨苄西林水平。
Br Med J. 1969 Jul 12;3(5662):88-9. doi: 10.1136/bmj.3.5662.88.
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Treatment of chronic typhoid carriers with ampicillin.用氨苄西林治疗慢性伤寒带菌者。
JAMA. 1971 Aug 16;217(7):913-5.
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