Busch M, Popp F A
Strahlentherapie. 1975 Jan;149(1):75-92.
The absorbed energy dose, in dependence on the irradiated tissue volume or tumor volume (dose-volume-relations) has great significance for the valuation of radiation injuries and of the prognosis of the disease. The present paper includes an analysis, formal demonstrations and interpretation of these relations. Clinical observations and radiobiological experiments in literature were the basis of the present investigation. The assessment is kept simple, the models derived from it interprete well the clinical findings. Through these models, radiobiological findings and clinical experimental principles are connected. This results in a clear conception of the future development of irradiation planning, and the application technique of radiation. The range of validity of the cited models includes the treated volumes usual in radiotherapy. An extrapolation to the cellulary area or to the whole body may only be made with great reservations.
吸收能量剂量取决于受照射的组织体积或肿瘤体积（剂量-体积关系），这对于评估放射损伤和疾病预后具有重要意义。本文对这些关系进行了分析、形式论证和解释。文献中的临床观察和放射生物学实验是本研究的基础。评估保持简单，从中得出的模型能很好地解释临床发现。通过这些模型，将放射生物学发现与临床实验原理联系起来。这为放射治疗计划和放射应用技术的未来发展提供了清晰的概念。所引用模型的有效范围包括放射治疗中常见的治疗体积。只有在非常谨慎的情况下，才可以外推到细胞层面或全身。
