Sauer O
Z Kinderheilkd. 1975;119(1):59-69. doi: 10.1007/BF00464697.
For several decades urticaria pigmentosa had been considered to be a benign and purely cutaneous disease, caused by infiltrations of tissue mast cells in the skin. Yet until 1962 at least 24 cases of systemic mastocytosis had been published. Sagher estimated the incidence of systemic mastocytosis as being in the region of about 10% of all cases of urticaria pigmentosa. A case of systemic mastocytosis in a 4-year-old child is described. Biopsy specimens were examined by electron microscopy to study the process of degranulation of tissue mast cells during which histamine and heparin are released.
几十年来，色素性荨麻疹一直被认为是一种良性的纯皮肤疾病，由皮肤中组织肥大细胞浸润引起。然而，直到1962年，至少已有24例系统性肥大细胞增多症的病例发表。萨赫尔估计系统性肥大细胞增多症的发病率约占所有色素性荨麻疹病例的10%。本文描述了一名4岁儿童的系统性肥大细胞增多症病例。通过电子显微镜检查活检标本，以研究组织肥大细胞脱颗粒过程，在此过程中组胺和肝素会释放出来。
