Kessler B, Witholt B
Institute of Biotechnology, ETH Hönggerberg HPT, CH-8093 Zürich, Switzerland.
J Biotechnol. 2001 Mar 30;86(2):97-104. doi: 10.1016/s0168-1656(00)00404-1.
Polyhydroxyalkanoates (PHAs) are bacterial storage materials which are accumulated by various bacteria under unbalanced growth conditions. Although PHAs are produced in larger amounts and are studied because of their plastic material properties, not much is known about the regulation of PHA accumulation and the regulatory interactions with the general cell metabolism. In this report, we point out the diversity of regulatory mechanisms involved in PHA metabolism, and present examples for factors acting at the transcription or enzymatic level.
聚羟基脂肪酸酯（PHA）是细菌的储存物质，在生长条件不均衡时，多种细菌均可积累此类物质。尽管PHA因其具有塑料材料特性而大量生产并得到研究，但关于PHA积累的调控以及与细胞整体代谢的调控相互作用，人们了解得并不多。在本报告中，我们指出了PHA代谢中涉及的调控机制的多样性，并列举了在转录或酶促水平上发挥作用的因素实例。
