Doerks T, Copley R, Bork P
European Molecular Biology Laboratory, 69012 Heidelberg, Germany.
Trends Biochem Sci. 2001 Mar;26(3):145-6. doi: 10.1016/s0968-0004(00)01769-2.
Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. Recent studies indicate a likely DNA-binding function for the DDT domain.
基于同源性的序列分析揭示，在溴结构域PHD指转录因子（BPTF）、BAZ家族的染色质重塑因子及其他假定的核蛋白中存在一个新结构域（DDT）。该结构域的特征是有许多保守的芳香族和带电荷残基，预计由三个α螺旋组成。最近的研究表明，DDT结构域可能具有DNA结合功能。
