PARP眼中的世界。

The world according to PARP.

作者信息

Smith S

机构信息

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, 2nd Floor, New York, NY 10016, USA.

出版信息

Trends Biochem Sci. 2001 Mar;26(3):174-9. doi: 10.1016/s0968-0004(00)01780-1.

DOI:10.1016/s0968-0004(00)01780-1

PMID:11246023

Abstract

An immediate cellular response to DNA damage is the synthesis of poly(ADP-ribose) by the enzyme poly(ADP-ribose) polymerase (PARP). This nuclear enzyme and the unique post-translational modification it catalyzes have long been considered to function exclusively in cellular surveillance of genotoxic stress. The recent identification of multiple members of a PARP family might force a revision of this concept. The novel primary structures and subcellular localizations for some of these PARPs suggests new and unexpected roles for poly(ADP-ribosyl)ation in telomere replication and cellular transport.

摘要

细胞对DNA损伤的即时反应是由聚（ADP - 核糖）聚合酶（PARP）合成聚（ADP - 核糖）。这种核酶及其催化的独特翻译后修饰长期以来一直被认为仅在细胞对基因毒性应激的监测中起作用。PARP家族多个成员的最近鉴定可能会促使对这一概念进行修正。其中一些PARP的新一级结构和亚细胞定位表明聚（ADP - 核糖基）化在端粒复制和细胞运输中具有新的、意想不到的作用。