Diefenbach J, Bürkle A
Molecular Toxicology Group, University of Konstanz, Box X911, 78457 Konstanz, Germany.
Cell Mol Life Sci. 2005 Apr;62(7-8):721-30. doi: 10.1007/s00018-004-4503-3.
Poly(ADP-ribosyl)ation is a posttranslational modification of proteins in eukaryotic cells catalysed by a family of NAD+ ADP-ribosyl transferases, the poly(ADP-ribose) polymerases (PARPs). PARP-encoding genes now constitute a superfamily of at least 18 members encoding proteins that share homology with the catalytic domain of the founding member, PARP-1. Poly(ADP-ribose) metabolism is of central importance in a wide variety of biological processes including maintenance of genomic stability, DNA repair, transcriptional regulation, centromere function, modulation of telomere length, regulation of proteasomal protein degradation, regulation of endosomal vesicle trafficking and apoptosis. The life cycle of poly(ADP-ribose) is discussed in the following section. In addition, an overview of the genes and proteins involved in poly(ADP-ribose) metabolism and their possible cellular function is provided.
聚（ADP-核糖）化是真核细胞中蛋白质的一种翻译后修饰，由一类NAD⁺ ADP-核糖基转移酶——聚（ADP-核糖）聚合酶（PARP）催化。PARP编码基因现构成一个至少有18个成员的超家族，这些成员编码的蛋白质与创始成员PARP-1的催化结构域具有同源性。聚（ADP-核糖）代谢在多种生物学过程中至关重要，包括维持基因组稳定性、DNA修复、转录调控、着丝粒功能、端粒长度调节、蛋白酶体蛋白降解调节、内体囊泡运输调节和细胞凋亡。聚（ADP-核糖）的生命周期将在以下部分讨论。此外，还提供了参与聚（ADP-核糖）代谢的基因和蛋白质及其可能的细胞功能概述。
