Covert M W, Schilling C H, Famili I, Edwards J S, Goryanin I I, Selkov E, Palsson B O
Dept Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA.
Trends Biochem Sci. 2001 Mar;26(3):179-86. doi: 10.1016/s0968-0004(00)01754-0.
The large volume of genome-scale data that is being produced and made available in databases on the World Wide Web is demanding the development of integrated mathematical models of cellular processes. The analysis of reconstructed metabolic networks as systems leads to the development of an in silico or computer representation of collections of cellular metabolic constituents, their interactions and their integrated function as a whole. The use of quantitative analysis methods to generate testable hypotheses and drive experimentation at a whole-genome level signals the advent of a systemic modeling approach to cellular and molecular biology.
万维网上数据库中正在产生并可供使用的大量基因组规模数据，要求开发细胞过程的综合数学模型。将重建的代谢网络作为系统进行分析，促使人们开发细胞代谢成分集合、它们的相互作用以及它们作为一个整体的综合功能的计算机模拟或计算机表示。使用定量分析方法来生成可检验的假设并推动全基因组水平的实验，标志着细胞和分子生物学系统建模方法的出现。
