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[动物实验中实验性炭疽诊断血清的制备及比较评估]

[Preparation and comparative evaluation of experimental anthrax diagnostic sera in experiments on animals].

作者信息

Kravets I D, Garin N S, Krutovskikh A V, Volkovoĭ K I, Fedorov V L

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1975 Jan(1):85-8.

PMID:1124613
Abstract

The authors present the results of studies on obtaining and comparative assessment of experimental anthrax diagnostic sera in experiments on various animals. Donkeys, sheep, horses, rabbits and monkeys (Papio hamadryas) were immunized with the STI-I vaccine by a single scheme. The activity of the obtained sera was tested in the diffuse precipitation reaction by the amount of the detected antibodies and the titre. The most active sera were obtained from donkeys and sheep: their titre was 5.5 and 4 times greater and amount of the detected antibodies 2.6--2 times greater than in the sera of horses used up to the present time as producers of diagnostic anthrax preparations. The least active sera were obtained from monkeys.

摘要

作者介绍了在对各种动物进行的实验中获取实验性炭疽诊断血清并进行比较评估的研究结果。采用单一方案用STI-I疫苗对驴、绵羊、马、兔子和猴子(阿拉伯狒狒)进行免疫。通过检测到的抗体量和效价,在扩散沉淀反应中测试所获血清的活性。从驴和绵羊获得的血清活性最高:其效价比目前用作诊断炭疽制剂生产源的马血清高5.5倍和4倍,检测到的抗体量比马血清高2.6至2倍。从猴子获得的血清活性最低。

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