Elbetieha A, Bataineh H, Darmani H, Al-Hamood M H
Department of Applied Biological Sciences, Faculty of Science, Jordan University of Science and Technology, P.O. Box 3030, 22110, Irbid, Jordan.
Toxicol Lett. 2001 Mar 8;119(3):193-201. doi: 10.1016/s0378-4274(00)00312-x.
The effect of long-term ingestion of manganese (II) chloride tetrahydrate was investigated on fertility of male and female Swiss mice. Adult male or female mice ingested a solution of manganese chloride along with drinking water at concentrations of 1000, 2000, 4000 and 8000 mg/l for 12 weeks. Fertility was significantly reduced in male mice exposed to manganese chloride solution at a concentration of 8000 mg/l, but not at the other concentrations. There were no treatment-related effects on the number of implantation sites, viable fetuses or the number of resorptions in female rats impregnated by males who had ingested manganese chloride. Fertility was not significantly reduced in female mice exposed to manganese chloride solution at all concentrations used in this study. However, the numbers of implantations and viable fetuses were significantly reduced in females exposed to manganese chloride solution at a concentration of 8000 mg/l. There was no significant effect on the number of resorbed fetuses in females exposed to manganese chloride solution compared to their control counterparts. Absolute body weight was not significantly affected in females exposed to manganese chloride solutions. However, ovarian weight was significantly increased in females exposed to manganese chloride solution at concentrations of 4000 and 8000 mg/l. A significant increase in the uterine weight was also observed at all concentrations used in the study. These results indicate that ingestion of manganese chloride by adult male and female mice causes some adverse effects on fertility and reproduction.
研究了长期摄入四水合氯化锰对瑞士雄性和雌性小鼠生育能力的影响。成年雄性或雌性小鼠饮用含有浓度为1000、2000、4000和8000mg/L氯化锰的溶液，持续12周。暴露于8000mg/L氯化锰溶液的雄性小鼠生育能力显著降低，但其他浓度组未出现此情况。对于摄入氯化锰的雄性小鼠使雌性大鼠受孕后的着床点数量、活胎数量或吸收胎数量，未发现与处理相关的影响。本研究中所有浓度的氯化锰溶液处理的雌性小鼠生育能力均未显著降低。然而，暴露于8000mg/L氯化锰溶液的雌性小鼠着床和活胎数量显著减少。与对照雌性相比，暴露于氯化锰溶液的雌性小鼠吸收胎数量无显著影响。暴露于氯化锰溶液的雌性小鼠绝对体重未受到显著影响。然而，暴露于4000和8000mg/L氯化锰溶液的雌性小鼠卵巢重量显著增加。在本研究使用的所有浓度下，子宫重量也显著增加。这些结果表明，成年雄性和雌性小鼠摄入氯化锰会对生育能力和繁殖产生一些不利影响。
