锰对常规精液质量参数的影响：来自中国的一项基于人群的研究结果。
Effects of manganese on routine semen quality parameters: results from a population-based study in China.
机构信息
Shanghai Institute of Planned Parenthood Research, Shanghai/WHO Collaborating Center on Human Research on Reproductive Health, 2140 Xietu Road, Shanghai 200032, China.
出版信息
BMC Public Health. 2012 Oct 29;12:919. doi: 10.1186/1471-2458-12-919.
BACKGROUND
Manganese (Mn) is an essential element in humans but its effect on semen quality is unclear. This study therefore aimed to assess the effects of Mn on semen quality in healthy men with no occupational exposure to Mn.
METHODS
Semen samples were obtained from healthy Chinese men 20-59 years old who were recruited from six provinces in China. Individuals with urogenital tract diseases, tuberculosis, or occupational exposure to heavy metals were excluded. A questionnaire survey was conducted, and the external genitalia, semen quality, and serum Mn levels were examined.
RESULTS
A total of 1,179 volunteers were enrolled in this study. The median serum Mn concentration was 8.2 μg/L (25th percentile (P25)=3.7 μg/L, P75=16.2 μg/L). After adjusted area (six provinces), abstinence interval, season, registered residence, age of subjects, education level, income, smoking, and drinking, the risk of teratospermia was increased at serum Mn concentrations >19.40 μg/L (P80) group, with an adjusted odds ratio of 2.27 (95% confidence interval: 1.18-4.37).
CONCLUSION
High serum Mn levels appeared to have harmful effects on sperm morphology and motility among healthy men with no occupational exposure to Mn.
背景
锰（Mn）是人体必需的微量元素，但它对精液质量的影响尚不清楚。因此，本研究旨在评估无职业性锰暴露的健康男性体内锰对精液质量的影响。
方法
本研究从中国 6 个省份招募了 20-59 岁健康的中国男性，获取其精液样本。排除患有泌尿生殖道疾病、结核病或职业性重金属接触者。通过问卷调查，对参与者的外生殖器、精液质量和血清锰水平进行了检测。
结果
本研究共纳入了 1179 名志愿者。血清锰浓度的中位数为 8.2μg/L（25 百分位数（P25）=3.7μg/L，P75=16.2μg/L）。经调整地区（6 个省份）、禁欲时间、季节、登记居住地、年龄、教育程度、收入、吸烟和饮酒因素后，血清锰浓度>19.40μg/L（P80）组的精子畸形风险增加，调整后的比值比为 2.27（95%置信区间：1.18-4.37）。
结论
对于无职业性锰暴露的健康男性，高血清锰水平似乎对精子形态和活力有不良影响。
Zotero 插件