Jin L, Baskett M L, Cavalli-Sforza L L, Zhivotovsky L A, Feldman M W, Rosenberg N A
Human Genetics Center, Universityof Texas-Houston, 77225, USA.
Ann Hum Genet. 2000 Mar;64(Pt 2):117-34. doi: 10.1017/S0003480000008034.
We genotyped 64 dinucleotide microsatellite repeats in individuals from populations that represent all inhabited continents. Microsatellite summary statistics are reported for these data, as well as for a data set that includes 28 out of 30 loci studied by Bowcock et al. (1994) in the same individuals. For both data sets, diversity statistics such as heterozygosity, number of alleles per locus, and number of private alleles per locus produced the highest values in Africans, intermediate values in Europeans and Asians, and low values in Americans. Evolutionary trees of populations based on genetic distances separated groups from different continents. Corresponding trees were topologically similar for the two data sets, with the exception that the (deltamu)2 genetic distance reliably distinguished groups from different continents for the larger data set, but not for the smaller one. Consistent with our results from diversity statistics and from evolutionary trees, population growth statistics S k and beta, which seem particularly useful for indicating recent and ancient population size changes, confirm a model of human evolution in which human populations expand in size and through space following the departure of a small group from Africa.
我们对来自代表所有有人居住大陆的人群个体中的64个二核苷酸微卫星重复序列进行了基因分型。报告了这些数据以及一个数据集的微卫星总结统计信息，该数据集包含Bowcock等人（1994年）在同一批个体中研究的30个位点中的28个。对于这两个数据集，诸如杂合度、每个位点的等位基因数量以及每个位点的私有等位基因数量等多样性统计数据在非洲人中的值最高，在欧洲人和亚洲人中为中间值，而在美国人中则为低值。基于遗传距离的种群进化树将来自不同大陆的群体区分开来。两个数据集的相应树在拓扑结构上相似，唯一的例外是（deltamu）2遗传距离对于较大数据集能够可靠地区分来自不同大陆的群体，但对于较小数据集则不行。与我们从多样性统计和进化树得出的结果一致，种群增长统计量Sk和β似乎对于指示近期和古代种群大小变化特别有用，它们证实了一种人类进化模型，即在一小群人离开非洲后，人类种群在规模上和空间上不断扩张。
