Boquist L, Fåhraeus B
Acta Pathol Microbiol Scand A. 1975 Jan;83(1):131-8.
Light-microscopic examinations were performed in three groups of pigs; one sham-operated control group, one group subjected to thyroidectomy (TX), and one group injected with parat-hormone (PTH) after thyroidectomy (TK + PTH). The kidneys of the sham-operated animals were normal, whereas slight to moderate dilatation of some tubules was seen in the TX group. The most prominent changes in the TX + PTH group were calcium deposition, tubular dilatation and degeneration, inflammation, and hyperaemia. In addition there were hyaline casts, PAS-positive globules and mitotic figures in the tubules. It is suggested that the calcium deposition caused by the PTH administration plays a major role in the development of degeneration in the tubular epithelium, and that these structural lesions are of importance in the development of reduced renal function.
对三组猪进行了光学显微镜检查；一组为假手术对照组，一组进行甲状腺切除术（TX），一组在甲状腺切除术后注射甲状旁腺激素（TK + PTH）。假手术动物的肾脏正常，而TX组可见一些肾小管轻度至中度扩张。TX + PTH组最显著的变化是钙沉积、肾小管扩张和变性、炎症以及充血。此外，肾小管内有透明管型、PAS阳性小球和有丝分裂象。提示甲状旁腺激素给药引起的钙沉积在肾小管上皮细胞变性的发展中起主要作用，并且这些结构损伤在肾功能降低的发展中具有重要意义。
