Gasbarrini A, Anti M, Franceschi F, Armuzzi A, Cotichini R, Ojetti V, Candelli M, Lippi M E, Paolucci M, Cicconi V, Cammarota G, Danese S, Silveri N G, Catananti C, Pola P, Stroffolini T, Gasbarrini G
Department of Medical Pathology, Gemelli Hospital, Catholic University, Rome, Italy.
Eur J Gastroenterol Hepatol. 2001 Feb;13(2):185-9. doi: 10.1097/00042737-200102000-00015.
To evaluate the prevalence of and the risk factors for Helicobacter pylori in a population of medical and non-medical workers at a teaching hospital in Rome, Italy.
A cross-sectional study.
From January to October 1998, 655 subjects (65% of the total population) underwent a 13C-urea breath test to assess H. pylori infection. Subjects completed a questionnaire concerning sociodemographic characteristics, work departments and history of some gastrointestinal symptoms. Differences in means and proportions were evaluated and independent predictors of H. pylori infection status were assessed by multiple logistic regression analysis.
Forty percent of the subjects were found to be H. pylori infected. The mean age of positive subjects was significantly higher than that of negative ones (38 +/- 14 versus 34 +/- 12 years; P < 0.01). No significant difference was found between males and females concerning the infection status (40.2% males versus 39.9% females). Lower years of father's education [odds ratio (OR), 3.1; 95% confidence interval (CI), 1.9-5.1] and age older than 35 years (OR, 2.0; 95% CI, 1.3-3.1) were the only independent predictors of the likelihood of H. pylori positivity. Prevalence of gastrointestinal symptoms was similar in infected and uninfected subjects. Physicians were significantly less infected than nurses and auxiliary personnel (26% versus 47% versus 55%, respectively); however, a loss of association was observed after adjustment by multiple logistic regression (OR, 1.8; 95% CI, 0.9-3.7). In all groups, some specific departments appear to be associated with a higher infection status.
Among healthcare workers, H. pylori infection was associated with specific sociodemographic characteristics, such as age and level of father's education. The prevalence of H. pylori infection was not associated with different professional categories. However, some specific departments seem to increase infection risk.
评估意大利罗马一家教学医院的医务人员和非医务人员群体中幽门螺杆菌的感染率及其危险因素。
一项横断面研究。
1998年1月至10月，655名受试者（占总人口的65%）接受了13C尿素呼气试验以评估幽门螺杆菌感染情况。受试者填写了一份关于社会人口学特征、工作部门以及一些胃肠道症状病史的问卷。评估均值和比例的差异，并通过多因素逻辑回归分析评估幽门螺杆菌感染状态的独立预测因素。
发现40%的受试者感染了幽门螺杆菌。阳性受试者的平均年龄显著高于阴性受试者（38±14岁对34±12岁；P<0.01）。男性和女性在感染状态方面未发现显著差异（男性为40.2%，女性为39.9%）。父亲受教育年限较低[比值比（OR），3.1；95%置信区间（CI），1.9 - 5.1]以及年龄大于35岁（OR，2.0；95%CI，1.3 - 3.1）是幽门螺杆菌阳性可能性的仅有的独立预测因素。感染和未感染受试者的胃肠道症状患病率相似。医生的感染率显著低于护士和辅助人员（分别为26%对47%对55%）；然而，经多因素逻辑回归调整后这种关联消失（OR，1.8；95%CI，0.9 - 3.7）。在所有组中，一些特定部门似乎与较高的感染状态相关。
在医护人员中，幽门螺杆菌感染与特定的社会人口学特征相关，如年龄和父亲的教育水平。幽门螺杆菌感染率与不同职业类别无关。然而，一些特定部门似乎会增加感染风险。
