Abdulla W, Frey R, Witzke G
MMW Munch Med Wochenschr. 1979 Aug 10;121(32-33):1051-4.
The principal aims of whole blood transfusion therapy are simultaneous volume substitution, raising the oxygen transport capacity and the replacement of clotting factors. The necessary control factors for volume substitution are described. It must be borne in mind that the blood undergoes changes during storage which among other things affects the ability of the blood to transport oxygen and the clotting potential. Not only the destruction of thrombocytes must be considered but also the loss of activity of the proaccelerin and the antihemophilic globulin A. For this reason for massive blood transfusions using older blood conserves it is recommended that the loss of activity be compensated by antihemophilic cryoprecipitate.
全血输血疗法的主要目的是同时进行容量替代、提高氧运输能力以及补充凝血因子。文中描述了容量替代所需的控制因素。必须牢记，血液在储存过程中会发生变化，这在一定程度上会影响血液运输氧气的能力和凝血潜能。不仅要考虑血小板的破坏，还要考虑前加速素和抗血友病球蛋白A活性的丧失。因此，对于使用保存时间较长的血液进行大量输血的情况，建议用抗血友病冷沉淀来补偿活性的丧失。
