Witzke G, Abdulla W
Anaesthesist. 1979 Jul;28(7):322-7.
During storage banked blood show changes as far as function and concentration of their corpuscular and plasmatic ingredients are concerned. Antihaemophilic globulin (factor VIII) and pro-accelerin (factor V) in particular lose their activities so quickly that only very few activities still remain after a storage period of 3-5 days. In connection with existing primary diseases but also in trauma and shock a dilution-coagulopathy caused by insufficient supply of factors VIII and V can develop during massive transfusion, and this especially with banked blood already stored over a longer period of time. Therapy of this disturbance of coagulation consists of substituting the missing coagulation factors under heparin protection.
在储存期间，库存血在其细胞成分和血浆成分的功能及浓度方面会发生变化。特别是抗血友病球蛋白（因子VIII）和前加速素（因子V）会迅速失去活性，以至于在储存3至5天后仅剩下极少的活性。在存在原发性疾病的情况下，以及在创伤和休克时，大量输血过程中可能会因因子VIII和V供应不足而引发稀释性凝血病，尤其是使用已经储存较长时间的库存血时。这种凝血障碍的治疗方法是在肝素保护下补充缺失的凝血因子。
