Jackson W G, Michalek J E
Air Force Research Laboratory, Brooks Air Force Base, Texas 78235-5250, USA.
J Expo Anal Environ Epidemiol. 2001 Jan-Feb;11(1):50-5. doi: 10.1038/sj.jea.7500146.
We summarize temporal changes in the distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) measurements made in serum drawn in 1987, 1992, and 1997 from 1419 Air Force Vietnam-era veterans who served as comparisons in a 20-year prospective study of health and exposure to herbicides and their TCDD contaminant in Air Force veterans of Operation Ranch Hand, the unit responsible for aerial spraying of Agent Orange and other herbicides in Vietnam. Among comparison veterans, TCDD levels decreased significantly with time at a rate of -- 0.25 parts per trillion per year. We also describe paired serum TCDD measurements in a subgroup of 33 veterans who had detectable levels in both 1987 and 1992. The paired measurements suggested that serum TCDD levels decreased with time, including those near the limit of detection.
我们总结了1987年、1992年和1997年从1419名越战时期空军退伍军人中抽取的血清中2,3,7,8-四氯二苯并对二恶英（TCDD）测量值分布随时间的变化情况。这些退伍军人在一项为期20年的前瞻性研究中作为对照组，该研究旨在调查健康状况以及接触除草剂及其TCDD污染物的情况，研究对象是负责在越南空中喷洒橙剂和其他除草剂的“牧场工人行动”的空军退伍军人。在对照组退伍军人中，TCDD水平随时间显著下降，下降速率为每年-0.25万亿分之一。我们还描述了33名退伍军人亚组的配对血清TCDD测量值，这些退伍军人在1987年和1992年的测量值均可检测到。配对测量结果表明，血清TCDD水平随时间下降，包括那些接近检测限的水平。
