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Serum concentrations and profiles of polychlorinated biphenyls in Taiwan Yu-cheng victims twenty years after the incident.事件发生二十年后台湾油症受害者血清中多氯联苯的浓度及分布情况。
Environ Pollut. 2005 Jul;136(1):71-9. doi: 10.1016/j.envpol.2004.12.001.
2
Profile of PCDD/F levels in serum of general Taiwanese between different gender, age and smoking status.
Sci Total Environ. 2005 Jan 20;337(1-3):31-43. doi: 10.1016/j.scitotenv.2004.06.021.
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J Toxicol Environ Health A. 2004;67(8-10):715-26. doi: 10.1080/15287390490428198.
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Fish consumption and other environmental exposures and their associations with serum PCB concentrations among Mohawk women at Akwesasne.阿克瓦斯内莫霍克族女性的鱼类消费及其他环境暴露情况及其与血清多氯联苯浓度的关联。
Environ Res. 2004 Feb;94(2):160-70. doi: 10.1016/s0013-9351(03)00133-6.
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Serum PCDD/F concentration distribution in residents living in the vicinity of an incinerator and its association with predicted ambient dioxin exposure.
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J Toxicol Environ Health A. 2003 Nov 14;66(21):2067-75. doi: 10.1080/713853984.
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Food as a source of dioxin exposure in the residents of Bien Hoa City, Vietnam.越南边和市居民中食物作为二噁英暴露源的情况。
J Occup Environ Med. 2003 Aug;45(8):781-8. doi: 10.1097/01.jom.0000085786.50835.71.
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J Toxicol Environ Health A. 2003 Jul 25;66(14):1287-93. doi: 10.1080/15287390306391.
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Concentrations of dioxins and other organochlorines (PCBs, DDTs, HCHs) in human milk from Seveso, Milan and a Lombardian rural area in Italy: a study performed 25 years after the heavy dioxin exposure in Seveso.意大利塞韦索、米兰及伦巴第大区一个农村地区母乳中二噁英和其他有机氯（多氯联苯、滴滴涕、六氯环己烷）的浓度：一项在塞韦索严重二噁英暴露25年后开展的研究
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长期居住在工业附近是否会对老年女性体内多氯二苯并对二恶英、多氯二苯并呋喃和多氯联苯的负荷产生影响？

Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women?

作者信息

Pless-Mulloli T, Edwards R, Howel D, Wood R, Paepke O, Herrmann T

机构信息

School of Population and Health Sciences, The Medical School, Newcastle upon Tyne, UK.

出版信息

Occup Environ Med. 2005 Dec;62(12):895-901. doi: 10.1136/oem.2004.018754.

DOI:10.1136/oem.2004.018754
PMID:16299100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1740943/
Abstract

BACKGROUND

For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample from the UK.

AIMS AND METHODS

The authors aimed to investigate whether long term residents close to a heavy chemical industrial complex (Teesside, UK) had a higher body burden and distinct pattern of PCDD/F and PCBs. We measured current levels of PCDD/F and PCBs in a population based sample of older women (mean 64 years, range 42-79 years). Forty women were recruited, 20 living near (zone A: 0.1-2.7 km) and 20 distant (zone C: 5-40 km) from industry during 2000-03. The authors ascertained occupational exposure to lung carcinogens, residential history, consumption of local produce, breast feeding, diet, and height and weight.

RESULTS

The mean body burden measured on lipid basis in ng/kg for the whole sample was: WHO-TEQ (PCDD/Fs): 29.9, 2378TCDD: 4.0, PCB 118:16200, PCB156: 13100. Body burdens were similar to others reported from industrialised countries, except that mean 2378TCDD was slightly higher. Mean ages, body mass index, and lifelong dietary patterns were similar in both zones. The authors found no significant difference in mean body burden levels between zones A and C before or after adjustment for covariates. All congener patterns were consistent with an urban background pattern, and there was no significant difference between congener compositions in the two zones. The TCDD body burden increased with age with accelerated increments above age 70.

CONCLUSION

Long term residency near heavy and chemical industry did not have an effect on women's body burden of PCDD/Fs and PCBs on Teesside, UK. The body burden of PCDD/F and PCBs was not a suitable biomarker for chronic, non-occupational exposure to industrial air pollution.

摘要

背景

对于环境与健康关联的回顾性研究，需要接触生物标志物。多氯二苯并二恶英和呋喃（PCDD/F）以及多氯联苯（PCB）在某些情况下是有用的标志物。这是对来自英国的基于人群样本中PCDD/F体内负荷的首次研究。

目的和方法

作者旨在调查长期居住在重型化学工业园区（英国提赛德）附近的居民是否具有更高的PCDD/F和PCB体内负荷以及不同的模式。我们在一个基于人群的老年女性样本（平均64岁，年龄范围42 - 79岁）中测量了PCDD/F和PCB的当前水平。招募了40名女性，其中20名居住在距离工业区较近（A区：0.1 - 2.7公里），20名居住在距离较远（C区：5 - 40公里），时间跨度为2000 - 2003年。作者确定了职业性接触肺癌致癌物、居住史、当地农产品消费情况、母乳喂养情况、饮食以及身高和体重。

结果

以脂质为基础测量的整个样本的体内负荷（单位：ng/kg）为：WHO - TEQ（PCDD/Fs）：29.9，2378TCDD：4.0，PCB 118：16200，PCB156：13100。体内负荷与其他工业化国家报告的情况相似，只是平均2378TCDD略高。两个区域的平均年龄、体重指数和终身饮食模式相似。作者发现在对协变量进行调整之前或之后，A区和C区的平均体内负荷水平没有显著差异。所有同系物模式均与城市背景模式一致，且两个区域的同系物组成没有显著差异。TCDD体内负荷随年龄增加，在70岁以上增加加速。

结论

在英国提赛德，长期居住在重型化学工业附近对女性的PCDD/Fs和PCBs体内负荷没有影响。PCDD/F和PCB的体内负荷不是慢性非职业性接触工业空气污染的合适生物标志物。