“牧场之手”行动退伍军人中四氯二苯并二恶英半衰期的决定因素
Determinants of TCDD half-life in veterans of operation ranch hand.
作者信息
Wolfe W H, Michalek J E, Miner J C, Pirkle J L, Caudill S P, Patterson D G, Needham L L
出版信息
J Toxicol Environ Health. 1994 Apr;41(4):481-8. doi: 10.1080/15287399409531858.
The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that half-life increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.
在“牧场工人行动”的337名成员中，2,3,7,8 - 四氯二苯并 - 对 - 二噁英（TCDD）的半衰期随体脂和年龄显著变化。“牧场工人行动”是负责在越南空中喷洒橙剂的空军部队。利用1982年和1987年采集的血清得出的配对TCDD测量值，我们研究了TCDD半衰期如何随体脂百分比（PBF）、PBF的相对变化以及年龄而变化。我们发现，半衰期随PBF增加而显著增加，随PBF的相对变化增加以及年龄增长而显著降低。这337名退伍军人中观察到的TCDD半衰期中位数为11.3年，非参数95%置信区间为10.0 - 14.1年。
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