Lloyd A W, Faragher R G, Denyer S P
Biomedical Materials Research Group, School of Pharmacy & Biomolecular Sciences, University of Brighton, UK.
Biomaterials. 2001 Apr;22(8):769-85. doi: 10.1016/s0142-9612(00)00237-4.
The maintenance of vision is a key determinant of healthy ageing. This has been facilitated over recent decades by the development of a wide range of implants and biomedical devices to correct the functional deficiencies of disease, age and ocular trauma. This brief overview provides an insight into the structure of this unique organ, the major physiological functions of the component tissues and the present state of the art with respect to modern ocular implants. The review focuses primarily on the existing limitations of existing ocular biomaterials used in the fabrication of contact lenses, intraocular lenses, glaucoma filtration implants, keratoprostheses, intracorneal implants, scleral buckles and viscoelastic replacement agents. The challenge of improving ocular compatibility and ensuring the longevity of indwelling ocular devices is addressed along with the need to improve the physicochemical and mechanical properties of existing ocular biomaterials.
维持视力是健康老龄化的关键决定因素。近几十年来，各种各样用于矫正疾病、年龄和眼外伤导致的功能缺陷的植入物和生物医学设备的发展推动了这一点。本简要概述深入介绍了这个独特器官的结构、组成组织的主要生理功能以及现代眼植入物的当前技术水平。该综述主要关注用于制造隐形眼镜、人工晶状体、青光眼滤过植入物、角膜移植片、角膜内植入物、巩膜扣带和粘弹性替代剂的现有眼生物材料的现有局限性。文中探讨了提高眼相容性和确保眼内留置装置使用寿命的挑战，以及改善现有眼生物材料的物理化学和机械性能的必要性。
