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The influence of carbenoxolone on steroid-induced ulcer and mucus secretion in the rat.

作者信息

Berg M, Geisel A, Necheles H

出版信息

Am J Dig Dis. 1975 Feb;20(2):134-7. doi: 10.1007/BF01072339.

DOI:10.1007/BF01072339
PMID:1124737
Abstract

In rats, gastric mucus was decreased by starvation. The administration of carbenoxolone sodium, prednisolone, or their combination to starved rats brought the level of gastric mucus to that of nonstarved controls. Concomitant treatment with carbenoxolone sodium did not prevent prednisolone-induced ulceration of the glandular stomach in starved rats. The ulcerations of the prostomach (squamous spithelium)induced by starvation were prevented by carbenoxolone sodium, prednisolone, or the combination of the two.

摘要

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引用本文的文献

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Carbenoxolone: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease.

本文引用的文献

1
Protection of gastric mucosa of the rat against ulceration by prefeeding with protein hydrolysates.通过预先喂食蛋白水解物对大鼠胃黏膜进行溃疡保护。
Proc Soc Exp Biol Med. 1948 Nov;69(2):369-73. doi: 10.3181/00379727-69-16725.
2
Acute perforation of duodenal ulcer during ACTH and cortisone therapy.
Gastroenterology. 1951 Jun;18(2):308-12.
3
Perforated duodenal ulcer associated with pituitary adrenocorticotropic hormone (ACTH) therapy.与垂体促肾上腺皮质激素(ACTH)治疗相关的十二指肠穿孔性溃疡。
生胃酮:其药理特性及在消化性溃疡疾病中的治疗效果综述
Drugs. 1976;11(4):245-307. doi: 10.2165/00003495-197611040-00002.
J Am Med Assoc. 1950 Nov 18;144(12):996. doi: 10.1001/jama.1950.62920120002007a.
4
Starvation ulcer in the mouse.小鼠的饥饿性溃疡
Am J Physiol. 1960 Mar;198:619-20. doi: 10.1152/ajplegacy.1960.198.3.619.
5
Major undesirable side-effects resulting from prednisolone and prednisone.泼尼松龙和泼尼松产生的主要不良副作用。
J Am Med Assoc. 1955 Jun 11;158(6):459-63. doi: 10.1001/jama.1955.02960060017005.
6
Role of gastric secretions in activation of peptic ulcers by corticotropin (ACTH).胃分泌物在促肾上腺皮质激素(ACTH)激活消化性溃疡中的作用。
J Am Med Assoc. 1955 May 7;158(1):27-32. doi: 10.1001/jama.1955.02960010029007.
7
TREATMENT OF GASTRIC ULCER WITH CARBENOXOLONE SODIUM AND OESTROGENS.用甘珀酸钠和雌激素治疗胃溃疡
Gut. 1965 Feb;6(1):19-24. doi: 10.1136/gut.6.1.19.
8
EFFECT OF PREDNISOLONE ON GASTRIC MUCUS CONTENT AND ON ULCER FORMATION.泼尼松龙对胃黏液含量及溃疡形成的影响
Proc Soc Exp Biol Med. 1963 Dec;114:545-50. doi: 10.3181/00379727-114-28728.
9
HISTOPATHOLOGY OF STEROID-INDUCED ULCERS. AN EXPERIMENTAL STUDY IN THE RAT.类固醇诱导性溃疡的组织病理学。大鼠实验研究
Arch Pathol. 1964 Apr;77:407-23.
10
Triterpenoid liquorice compound in gastric and duodenal ulcer.三萜类甘草化合物与胃溃疡和十二指肠溃疡
Lancet. 1962 Dec 1;2(7266):1166-7. doi: 10.1016/s0140-6736(62)90926-1.