Domschke W, Domschke S, Hagel J, Demling L, Croft D N
Gut. 1977 Oct;18(10):817-20. doi: 10.1136/gut.18.10.817.
Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In normal subjects there was a negative correlation (p less that 0-025) between gastric DNA loss and NANA secretion; the lower the cell turnover the higher the NANA production. In gastric ulcer patients DNA loss or turnover was significantly (p less than 0-01) higher than normal, and fell significantly (p less than 0-01) after four weeks' treatment with carbenoxolone when 16 of the 17 ulcers had healed. At the same time NANA output increased significantly (p less than 0-01). It is suggested that patients with gastric ulcer lose cells at a high rate, a state of affairs which is returned towards normal by carbenoxolone, thus allowing the epithelial cells to mature within the mucosa and produce more mucus.
对19名健康受试者以及17名胃溃疡患者在使用甘珀酸治疗溃疡愈合前后进行了研究。测量胃脱氧核糖核酸（DNA）损失作为上皮细胞更新的指标，测量胃液中N-乙酰神经氨酸（NANA）含量作为黏液分泌的指标。在正常受试者中，胃DNA损失与NANA分泌之间呈负相关（p小于0.025）；细胞更新越低，NANA产生越高。胃溃疡患者的DNA损失或更新显著高于正常水平（p小于0.01），在17例溃疡中有16例愈合的情况下，使用甘珀酸治疗四周后DNA损失或更新显著下降（p小于0.01）。同时，NANA产量显著增加（p小于0.01）。提示胃溃疡患者细胞丢失率高，甘珀酸可使这种情况恢复正常，从而使上皮细胞在黏膜内成熟并产生更多黏液。
