Higgs R H, Castell D O
Am J Dig Dis. 1975 Mar;20(3):195-200. doi: 10.1007/BF01070721.
Recently cholinergic stimulation of the lower esophageal sphincter (LES) with bethanechol has been shown to be effective in the treatment of chronic gastroesophageal reflux. Since chronic reflux and esophagitis also occur in patients with vagotomy and antrectomy, we studied the effect of bethanechol on sphincter pressure in 10 patients who had had vagotomy and antrectomy. Both subcutaneous (0.08 mg/kg) and oral (25 mg) administration of bethanechol caused significant increases in LES pressure in these patients. In addition, both subcutaneous and oral administration of bethanechol elevated hypotensive sphincter pressures to normal levels. Orally administered bethanechol produced a sustained increase in LES pressure throughout a 90-min study period. These studies suggest that cholinergic stimulation of the LES with bethanechol may be of therapeutic benefit in vagotomized and antrectomized patients with gastroesophageal reflux.
最近已表明，使用氨甲酰甲胆碱对食管下括约肌（LES）进行胆碱能刺激在治疗慢性胃食管反流方面是有效的。由于迷走神经切断术和胃窦切除术患者也会发生慢性反流和食管炎，我们研究了氨甲酰甲胆碱对10例接受迷走神经切断术和胃窦切除术患者的括约肌压力的影响。皮下注射（0.08 mg/kg）和口服（25 mg）氨甲酰甲胆碱均使这些患者的LES压力显著升高。此外，皮下和口服氨甲酰甲胆碱均可将低血压的括约肌压力提高到正常水平。在整个90分钟的研究期间，口服氨甲酰甲胆碱使LES压力持续升高。这些研究表明，用氨甲酰甲胆碱对LES进行胆碱能刺激可能对患有胃食管反流的迷走神经切断术和胃窦切除术患者具有治疗益处。
