McCallum R W, Kline M M, Curry N, Sturdevant R A
Gastroenterology. 1975 May;68(5 Pt 1):1114-8.
The effects of oral metoclopramide, 10 and 20 mg, bethanechol, 25 mg, and placebo on lower esophageal sphincter pressure (LESP) were studied in 15 men with symptoms of gastroesophageal reflux and basal LESP less than 11 mm Hg. Each drug produced a significant increase in LESP when compared to placebo. Metoclopramide, 20 mg, produced a greater increase than either metoclopramide, 10 mg, or bethanechol, 25 mg. Serum gastrin concentrations were not altered by any of the drugs. Side effects were unremarkable. The LESP increasing effect of metoclopramide might be useful in treatment of gastro-esophageal reflux.
对15名有胃食管反流症状且基础下食管括约肌压力（LESP）低于11毫米汞柱的男性，研究了口服10毫克和20毫克胃复安、25毫克氨甲酰甲胆碱及安慰剂对下食管括约肌压力的影响。与安慰剂相比，每种药物均使下食管括约肌压力显著升高。20毫克胃复安产生的升高幅度大于10毫克胃复安或25毫克氨甲酰甲胆碱。所有药物均未改变血清胃泌素浓度。副作用不明显。胃复安增加下食管括约肌压力的作用可能对胃食管反流的治疗有用。
