Sondheimer J M, Arnold G L
J Pediatr Gastroenterol Nutr. 1986 Jan;5(1):47-51. doi: 10.1097/00005176-198601000-00009.
Lower esophageal sphincter (LES) pressure, as well as esophageal peristaltic amplitude, duration, and velocity were measured in 16 infants with gastroesophageal reflux before administration of subcutaneous bethanechol, and at 10, 20, and 30 min after. Seven infants received 0.1 mg/kg, and 9 received 0.2 mg/kg. Significant increases in LES pressure occurred at both doses and lasted for 20 min. The amplitude and duration of peristaltic contractions were increased only after the larger bethanechol dose, and the increases were of greater magnitude in the distal esophagus than in the middle esophagus. The velocity of peristalsis decreased significantly in both the lower and middle esophagus, but only after the larger dose of bethanechol. Bethanechol had no effect on any motor function of the upper third of the esophagus. The changes in esophageal peristalsis produced by bethanechol may improve the efficiency of distal esophageal acid clearance and thus may be responsible in part for the therapeutic effect of bethanechol in infants with gastroesophageal reflux.
在16例胃食管反流婴儿皮下注射氨甲酰甲胆碱前、注射后10分钟、20分钟和30分钟，测量其食管下括约肌（LES）压力以及食管蠕动幅度、持续时间和速度。7例婴儿接受0.1mg/kg剂量，9例接受0.2mg/kg剂量。两种剂量下LES压力均显著升高，并持续20分钟。仅在较大剂量的氨甲酰甲胆碱注射后，蠕动收缩的幅度和持续时间增加，且远端食管的增加幅度大于食管中段。食管下段和中段的蠕动速度均显著降低，但仅在较大剂量的氨甲酰甲胆碱注射后出现。氨甲酰甲胆碱对食管上三分之一的任何运动功能均无影响。氨甲酰甲胆碱引起的食管蠕动变化可能会提高远端食管酸清除效率，因此可能部分解释了氨甲酰甲胆碱对胃食管反流婴儿的治疗效果。
