Rahman M, Alam A, Nessa K, Nahar S, Dutta D K, Yasmin L, Monira S, Sultan Z, Khan S A, Albert M J
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Clin Infect Dis. 2001 Mar 15;32(6):884-9. doi: 10.1086/319345. Epub 2001 Mar 9.
Although ciprofloxacin is one of the recommended drugs of choice for the treatment of gonorrhea, in vitro resistance to this drug has been observed in surveillance studies and case reports from many parts of the world, including Bangladesh. However, to our knowledge, there have been no prospective studies of the correlation between in vitro response to the drug and treatment outcome. Therefore, a prospective study of 217 female sex workers in Dhaka, Bangladesh, was conducted to examine the correlation between the in vitro response of Neisseria gonorrhoeae and the outcome of ciprofloxacin treatment. Overall, 37.8% of the gonococcal isolates recovered from female sex workers were resistant to ciprofloxacin, and there was a good correlation between in vitro resistance and treatment failure. These findings suggest that in vitro resistance to ciprofloxacin is predictive of clinical treatment failure in patients with gonorrhea.
尽管环丙沙星是治疗淋病的推荐首选药物之一，但在包括孟加拉国在内的世界许多地区的监测研究和病例报告中都观察到了对该药物的体外耐药性。然而，据我们所知，尚未有关于该药物体外反应与治疗结果之间相关性的前瞻性研究。因此，在孟加拉国达卡对217名女性性工作者进行了一项前瞻性研究，以检验淋病奈瑟菌的体外反应与环丙沙星治疗结果之间的相关性。总体而言，从女性性工作者中分离出的淋球菌菌株中有37.8%对环丙沙星耐药，并且体外耐药性与治疗失败之间存在良好的相关性。这些发现表明，对环丙沙星的体外耐药性可预测淋病患者的临床治疗失败。
