以色列特拉维夫淋病奈瑟菌对环丙沙星高水平耐药的高流行率：与治疗反应的相关性
High prevalence of high-level ciprofloxacin resistance in Neisseria gonorrhoeae in Tel Aviv, Israel: correlation with response to therapy.
作者信息
Dan Michael, Poch Francesca, Sheinberg Bracha
机构信息
Infectious Diseases Unit, E. Wolfson Hospital, Holon. Central Laboratory, Maccabi Health Services, Rishon-le-Zion, Israel.
出版信息
Antimicrob Agents Chemother. 2002 Jun;46(6):1671-3. doi: 10.1128/AAC.46.6.1671-1673.2002.
Abstract
A survey of the drug susceptibilities of gonococcal isolates from 100 consecutive patients attending clinics in the Tel Aviv area of Israel during the period from February to September 2000 has shown a 61% rate of ciprofloxacin resistance (MICs, > or =1 microg/ml); 51 isolates were highly resistant (MICs, > or =4 microg/ml). Ciprofloxacin-resistant strains were more prevalent among isolates with chromosomally mediated resistance to penicillin and tetracycline. Therapeutic failures with ciprofloxacin correlated with MICs of > or =1 mg/ml (P < 0.01). The high rate of ciprofloxacin resistance coinciding with a sharp rise in the incidence of gonorrhea precludes the use of fluoroquinolone drugs for the empirical treatment of gonococcal infections acquired in Israel.
摘要
对2000年2月至9月期间在以色列特拉维夫地区诊所就诊的100例连续患者的淋球菌分离株进行的药敏试验显示，环丙沙星耐药率为61%（MICs，≥1μg/ml）；51株高度耐药（MICs，≥4μg/ml）。对青霉素和四环素具有染色体介导耐药性的分离株中，环丙沙星耐药菌株更为普遍。环丙沙星治疗失败与MICs≥1mg/ml相关（P<0.01）。环丙沙星耐药率高，同时淋病发病率急剧上升，这使得氟喹诺酮类药物无法用于以色列获得性淋球菌感染的经验性治疗。
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