Semenza G L
Johns Hopkins Hospital, CMSC-1004, 600 North Wolfe Street, Baltimore, Maryland 21287-3914, USA.
Curr Opin Cell Biol. 2001 Apr;13(2):167-71. doi: 10.1016/s0955-0674(00)00194-0.
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1 alpha transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1 alpha under non-hypoxic conditions but inhibits hypoxia-induced HIF-1 alpha expression.
缺氧诱导因子1（HIF-1）是一种氧调节转录激活因子，在哺乳动物发育、生理和疾病发病机制中发挥着重要作用。HIF-1α亚基会经历由冯·希佩尔-林道蛋白介导的氧依赖性泛素化和蛋白酶体降解。缺氧可诱导HIF-1α反式激活结构域与共激活因子相互作用。信号转导途径仍不清楚，但涉及活性氧的产生。一氧化氮在非缺氧条件下可诱导HIF-1α，但会抑制缺氧诱导的HIF-1α表达。
